Uterine Artery Doppler Changes from the Second Trimester of Pregnancy to the Postpartum Period in a Group of High Risk Women - DOH-Net
The Diabetes, Obesity and Hypertension in Pregnancy Research Network (DOH-Net) is a multi-disciplinary research team of obstetrical, midwifery and maternal-fetal medicine specialists.
DOH-Net, research, diabetes, hypertension, obesity, pregnancy, gestational diabetes, diabetes, obesity and hypertension in pregnancy research network, Sunnybrook Health Sciences Centre, St. Michael's Hospital, McMaster University, obstetrics, midwife, maternal-fetal medicine, specialists, researchers, Toronto, Ontario, Canada, Hamilton, Greater Toronto Area, GTA
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Uterine Artery Doppler Changes from the Second Trimester of Pregnancy to the Postpartum Period in a Group of High Risk Women

In uncomplicated pregnancies, the uterine spiral arteries undergo a series of structural changes that result in a low resistance in the uterine arteries as pregnancy progresses. In many pregnancies complicated with preeclampsia, growth restrictions, and other placental-related complications, the described change does not occur. In pregnancies at high risk for placental complications, doppler measurement of Uterine artery flow has been shown to be a reliable predictor of complications. Post-partum, there is a reversal of vascular changes seen in normal pregnancies. It is unclear if there is a full reversal of these changes in complicated pregnancies with abnormal flow during pregnancy. The aim of our study is to follow the post-partum dopplers of women who had normal and abnormal flow during pregnancy. We hypothesize that Doppler uterine artery measurements after complicated pregnancies will show some abnormality compared to doppler measurements following uncomplicated pregnancies.

This is an observational prospective study. It does not involve any drug or treatment interventions. The study recruits women that have recently delivered and have undergone a Uterine Doppler ultra sound (US) during the second trimester of their pregnancy. Eligible women will undergo one ultrasound examination. The post natal uterine doppler is for research purposes only.  The ultrasound examinations will be performed on your abdomen. The examination includes a measurement of blood flow in the Uterine arteries. The entire length of the study is expected to take no more than 5-10 minutes, and may include an up to 15-minute waiting time due to US availability. Later, we will access your St. Michael’s Hospital medical record in order to gain information about your pregnancy, including information from the 2nd trimester US,  and delivery.

Study Contact
Karizma Mawjee, mawjeek@smh.ca