Advanced Maternal Age in Twins in Women with and without Diabetes, Obesity, and Hypertension - DOH-Net
The Diabetes, Obesity and Hypertension in Pregnancy Research Network (DOH-Net) is a multi-disciplinary research team of obstetrical, midwifery and maternal-fetal medicine specialists.
DOH-Net, research, diabetes, hypertension, obesity, pregnancy, gestational diabetes, diabetes, obesity and hypertension in pregnancy research network, Sunnybrook Health Sciences Centre, St. Michael's Hospital, McMaster University, obstetrics, midwife, maternal-fetal medicine, specialists, researchers, Toronto, Ontario, Canada, Hamilton, Greater Toronto Area, GTA
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Advanced Maternal Age in Twins in Women with and without Diabetes, Obesity, and Hypertension

Research  has  shown  that  increased  likelihood  of  pregnancy  complications  in  women  of  an  advanced  age  may  be  due  to  aging  of  the  uterus. Given that twin pregnancies place a greater burden on the uterus, women  of  advanced age  expecting  twins  will  more  likely  face  pregnancy  complications  compared  to  singleton  pregnancies.  However  some research  finds  that  pregnancy  outcomes  for  twins  are  worse  while  others  find  that  twin  pregnancies  may  actually  fare  better.  Reasons  for  the  inconsistency  include:  lack  of  a  consistent  definition  for  advanced  age;  failure  to  address  potential  outside  influences  like  BMI; and lack  of  a  single  pregnancy  comparison  group.  This retrospective study  attempts  to  address  these  gaps by  looking  at  all  women  who  gave birth  in  Ontario from  April  2012  to March  2017 from the Better Outcomes Registry and Network (BORN) database. The  aim  is  to  test  the  hypothesis  that  the  association  of  advanced  maternal  age  with  adverse  pregnancy  and  neonatal  outcomes  in  twin  gestations  is  greater  than  that  observed  in  singleton  gestations.

Contact for this study:
Isabel Arruda, isabel.arruda@sunnybrook.ca